Research Profile

Research Areas

Reproduction.MS is characterised by its integrated approach, investigating both the fundamental aspects of reproduction and the pathomechanisms of infertility. In Münster, our focus is on male infertility. Additionally, we are advancing projects on fertility preservation and restoration, both before and after oncological treatments. To achieve this, we integrate interdisciplinary research across molecular and cell biology, physiology, (epi-)genetics, evolution, and (bio)informatics with multimodal data analysis.

Local Collaborative Research Projects

University Research and Treatment Centre (URTC) “Reproductive Health”

The URTC “Reproductive Health” at the Medical Faculty of Münster comprises over 44 researchers from 27 institutes and clinics, focusing on infertility, embryonic development, and the mechanisms that control embryo implantation and pregnancy. These include oncological research, as well as gonadal tumours, the interplay between infertility and oncogenes, and the fertility preservation measures required before oncological treatments. The primary goal of the URTC is to forge a close connection between medicine, clinical science, and basic research, thereby accelerating the translation of new findings into clinical practice.

DFG Clinical Research Unit “Male Germ Cells: from Genes to Function” (CRU326)

The DFG Clinical Research Unit CRU326, with its 13 principal investigators and 10 projects, aims to elucidate the genetic and epigenetic causes of male infertility, as well as the molecular mechanisms essential for germ cell function. The complex molecular regulation of sperm production and function is examined using innovative technologies to identify potential causes of infertility, thereby offering valuable information for diagnosis and treatment. These research objectives are achieved primarily through the cross-project utilisation and analysis of central biobanks and databases.

BMBF Junior Scientist Research Centre “ReproTrack.MS”

The BMBF-funded Junior Scientist Research Centre “ReproTrack.MS” offers ten postdoctoral reproductive medical and clinician scientists a structured programme to advance their academic careers. The programme aims to guide participants through their research projects while strategically supporting the achievement of key career milestones, including habilitation. To this end, a team of 15 principal investigators has been assembled to offer mentoring, workshops, and seminars. The research programme of ReproTrack.MS builds on existing expertise and spans the spectrum from genetic causes of infertility and comorbidities, testis development and fertility preservation, over sperm dysfunction and ciliopathies, to fertilisation and implantation. Research within ReproTrack.MS occurs at the interface between basic research and clinical practice, providing a unique opportunity to network, and collaboratively foster the translational goals of reproductive research in Münster.

Initiative for a DFG Collaborative Research Centre “Reproduction.MS” (CRC 1748)

The CRC initiative “Reproduction.MS” will continue to expand and enhance previous efforts to establish a beacon of excellence in deciphering the molecular mechanisms of male infertility. By utilising innovative research approaches und cutting-edge technologies, the initiative aims to generate new insights and therapeutic approaches.